The flight was headed from Vancouver to Chicago but had to make a landing in Seattle.
In a statement, American Airlines said the flight was headed from Vancouver to Seattle.
An FAA spokesman confirmed that a tire on the plane blew out, causing the flight to declare an emergency.
The flight landed at Seattle just before 2 p.m. local time. An FAA spokesman said the flight landed safely and the runway will be closed for approximately 30 minutes.
The aircraft is currently being inspected at the gate. Approximately 157 passengers are on board.
American Airlines said the passengers would be moved to a different aircraft if necessary.