BOWIE, Md. —

A small plane went down on U.S. Route 50 near Freeway Airport in Bowie, hitting a vehicle and injuring four people, authorities said.

Maryland State Police said troopers were called around 11:20 a.m. Thursday to eastbound Route 50 at Church Road for a plane crash.

State police said investigators believe the pilot was attempting to take off from Freeway Airport at the time of the crash. The exact cause of the crash has yet to be determined.

State police said the plane struck at least one car, a Nissan Versa, in the eastbound lanes of Route 50.

The pilot of the plane, identified as Julius Tolson Jr., 58, of Laurel, and the passenger of the plane, Michael Garrah, 57, of Columbia, were treated at the scene by Prince George’s County Fire and EMS crew members, state police said.

The driver of the car, Ryan McClain, 29, of Washington, D.C., and his passenger, Eric Diprospero, 31, of Baltimore, were taken to hospitals.

Preliminary reports indicate neither drugs nor alcohol were a factor in the crash.

The Maryland State Highway Administration said two left lanes on eastbound Route 50 were closed and one lane on westbound Route 50 was closed. State police tweeted at 4 p.m. that all lanes have been reopened and the plane was removed from the highway.